MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels
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چکیده
منابع مشابه
MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels.
Restless legs syndrome (RLS) is a common neurological disorder characterized by an irresistible urge to move the legs at night, which is often accompanied by unpleasant sensations. A recent genomewide association study identified an association between RLS and intronic markers from the MEIS1 gene. Comparative genomic analysis indicates that MEIS1 is the only gene encompassed in this evolutionar...
متن کاملRestless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.
Genome-wide association studies (GWAS) identified the MEIS1 locus for Restless Legs Syndrome (RLS), but causal single nucleotide polymorphisms (SNPs) and their functional relevance remain unknown. This locus contains a large number of highly conserved noncoding regions (HCNRs) potentially functioning as cis-regulatory modules. We analyzed these HCNRs for allele-dependent enhancer activity in ze...
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conclusions we conclude that a significant percentage of esrd patients undergoing maintenance hd have severe or very severe rls symptoms. the presence of rls is associated to longer durations of dialysis. results of the 139 hd patients enrolled in this study, 60 were female (43.2%) and 79 were male (56.8%), with a mean age of 51.82 ± 13.31 years. the prevalence of rls was 15.8% (22 patients), w...
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OBJECTIVE Restless legs syndrome (RLS) is a common neurologic disorder. Secondary RLS includes pregnancy and iron deficiency. Prevalence of RLS in pregnancy ranges from 11% to 27%. We aimed to assess the frequency and characteristics of RLS in pregnancy in a Peruvian population and to evaluate the possible pregnancy or delivery complications due to RLS. METHODS We assessed 218 consecutive exp...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2009
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddn443